Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial

Using the data from trial of Metformin and AcaRbose in Chinese as initial Hypoglycemic treatment (MARCH), this study was performed to compare differential effects acarbose metformin on glucose metabolism after stratification by gender. Six hundred forty patients who had finished whole 48-week follow-up were included. The reduction haemoglobin A1c (HbA1c) comparable between acarbose- metformin-treated among either females or males, it also similar males treated with for 24 48 weeks. dropping fasting plasma (FPG) acarbose-treated significantly less than that at both Furthermore, decrease 2-hour postprandial (2hPPG) greater Multiple linear regression analysis showed drug selection an independent factor affecting FPG female while independently influenced 2hPPG week 48. reductions different although gender not regulating factor. Our indicates there might be gender-differential when comparisons are made treatments.